{"id":20665,"date":"2011-08-11T22:32:53","date_gmt":"2011-08-11T22:32:53","guid":{"rendered":"http:\/\/ergo21.com\/ergoblog\/?p=1"},"modified":"2025-03-17T04:45:21","modified_gmt":"2025-03-17T04:45:21","slug":"more-evidence-vitamin-d-boosts-immune-response","status":"publish","type":"post","link":"https:\/\/www.ergo21.com\/staging\/more-evidence-vitamin-d-boosts-immune-response\/","title":{"rendered":"More Evidence Vitamin D Boosts Immune Response"},"content":{"rendered":"<p>ScienceDaily \u2014 Laboratory-grown gingival cells treated with vitamin D boosted their production of an endogenous antibiotic, and killed more bacteria than untreated cells, according to a paper in the June 2011 issue of the journal <em>Infection and Immunity.<\/em> The research suggests that vitamin D can help protect the gums from bacterial infections that lead to gingivitis and periodontitis. Periodontitis affects up to 50 percent of the US population, is a major cause of tooth loss, and can also contribute to heart disease. Most Americans are deficient in vitamin D.<\/p>\n<hr \/>\n<p>His interest piqued by another laboratory&#8217;s discovery that vitamin D could stimulate white blood cells to produce natural proteins that have antibiotic activity, Gill Diamond of the UMDNJ &#8212; New Jersey Dental School, Newark, showed that vitamin D could stimulate lung cells to produce LL-37, a natural antibiotic protein, and kill more bacteria. That suggested that , vitamin D might help cystic fibrosis patients. Next, in the new research, he showed that vitamin D has the same effect on gingival cells.<\/p>\n<p>Then, Diamond found that vitamin D also stimulates gingival cells to produce another protein, called TREM-1, which had not been well-studied, but which was thought to be made by white blood cells. He found that it boosts production of pro-inflammatory cytokines.<\/p>\n<p>The new research also showed that vitamin D coordinates expression of a number of genes not previously considered to be part of the vitamin D pathway. Those genes may be involved in additional infection-fighting pathways. A more comprehensive understanding of how vitamin D carries out this regulation at the molecular level &#8212; something Diamond hopes to investigate &#8212; will enable targeted therapies using vitamin D, he says.<\/p>\n<p>Interestingly, Diamond also found that lung and gum cells appear to have the ability to activate inactive forms of vitamin D, says Diamond. &#8220;This means that we may even be able to use vitamin D therapy topically, if that proves true.&#8221;<\/p>\n<p>Vitamin D has become a hot area of research in recent years. In addition to infectious diseases, studies suggest that it has protective effects against autoimmune diseases, and certain cancers.<\/p>\n<p>Diamond says that after he began conducting research on vitamin D, he began taking it as a supplement. Since then, &#8220;I have had only one cold in four years, and that one lasted only three days,&#8221; he says. &#8220;Other people I&#8217;ve met who have done the same have seen similar results. We are trying to figure out how it&#8217;s working, and what other infectious diseases can be mitigated by it.&#8221;<\/p>\n<p><strong>Story Source:<\/strong><\/p>\n<p>The above story is reprinted (with editorial adaptations by Science<em>Daily<\/em> staff) from materials provided by <strong><u>American Society for Microbiology<\/u><\/strong>, via EurekAlert!, a service of AAAS.<\/p>\n<hr \/>\n<p><strong>Journal Reference<\/strong>:<\/p>\n<ol>\n<li>L. McMahon, K. Schwartz, O. Yilmaz, E. Brown, L. K. Ryan, G. Diamond. <strong>Vitamin D-Mediated Induction of Innate Immunity in Gingival Epithelial Cells<\/strong>. <em>Infection and Immunity<\/em>, 2011; 79 (6): 2250 DOI: 10.1128\/IAI.00099-11<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>The research suggests that vitamin D can help protect the gums from bacterial infections that lead to gingivitis and periodontitis. 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